After decades in hiding, Selene (Kate Beckinsale) is forced back into the underworld when a savage new vampire faction rises, led by a mysterious pureblood born from ancient corruption. As humans, Lycans, and vampires teeter on the brink of all-out extinction, Selene must forge uneasy alliances โ including with a young human-vampire hybrid boy who may hold the secret to halting the vampire plague.
Hunted by deadly mutant enforcers and haunted by the ghosts of her past, Selene embraces her darkest instincts. Together with her loyal ally David and a rebellious vampire queen, she launches a brutal counterstrike against the vampire uprising, plunging deep into the heart of a ruined city crawling with nightmarish creatures.
Explosive action, high-stakes betrayals, and blood-drenched battles push Selene to the edge โ and into a final confrontation that will decide the fate of both vampires and humankind.